2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130861
    Mal-NH-PEG4-CH2CH2COOPFP ester 1347750-84-8
    Mal-NH-PEG4-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH-PEG4-CH2CH2COOPFP ester
  • HY-140866
    N-(Azido-PEG4)-N-bis(PEG4-NHS ester) 2353409-90-0
    N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG4)-N-bis(PEG4-NHS ester)
  • HY-138481
    Boc-PEG4-methyl propionate 2100306-74-7
    Boc-PEG4-methyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-PEG4-methyl propionate
  • HY-134730
    N-Acetylpyrrolidine-PEG2-Br 3026716-99-1
    N-Acetylpyrrolidine-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Acetylpyrrolidine-PEG2-Br
  • HY-140794
    Azido-PEG3-C-Boc 172531-36-1
    Azido-PEG3-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C-Boc
  • HY-132020
    Tos-PEG2-THP 69502-32-5
    Tos-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-THP
  • HY-125888
    Boc-NH-C6-amido-C4-acid 10436-21-2
    Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-C6-amido-C4-acid
  • HY-138511
    NHS ester-PEG7-COOH
    NHS ester-PEG7-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NHS ester-PEG7-COOH
  • HY-133369
    DBCO-NHCO-PEG3-acid 2740473-26-9
    DBCO-NHCO-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG3-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG3-acid
  • HY-W1048572I
    N3-PEG20000-NH2
    N3-PEG20000-NH2 (Azide-PEG20000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG20000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester.
    N3-PEG20000-NH2
  • HY-140427
    Boc-Aminooxy-PEG3-C2-NH2 1235514-18-7
    Boc-Aminooxy-PEG3-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG3-C2-NH2
  • HY-140019
    Azido-PEG3-amide-C3-triethoxysilane 2243566-43-8
    Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-amide-C3-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-amide-C3-triethoxysilane
  • HY-134679
    N-Boc-C1-PEG5-C3-NH2 956472-77-8
    N-Boc-C1-PEG5-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-C1-PEG5-C3-NH2
  • HY-140901
    Biotin-PEG23-amine
    Biotin-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG23-amine
  • HY-141280
    Methyltetrazine-PEG24-NH-Boc
    Methyltetrazine-PEG24-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG24-NH-Boc
  • HY-133373
    DBCO-NHCO-PEG6-maleimide 3107769-85-4
    DBCO-NHCO-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG6-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG6-maleimide
  • HY-W1048572A
    N3-PEG2000-NH2
    N3-PEG2000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG2000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester.
    N3-PEG2000-NH2
  • HY-140778
    Azide-PEG5-Boc 1415800-41-7
    Azide-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG5-Boc
  • HY-W096150
    Dimethylamino-PEG3 2741-30-2
    Dimethylamino-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dimethylamino-PEG3
  • HY-141327
    Thiol-PEG3-Boc 1446282-39-8
    Thiol-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG3-Boc
PROTAC Linkers Isoform Comparison

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